Ning Jiang

Associate Professor

Ning Jiang

PhD

1066 Bogue St, Room A330
East Lansing, MI 48824

Phone: 517-353-0381

Area of Expertise: Function of transposable elements; mechanisms of genome diversification; computational and molecular biology.

Quick links: Education    Publications    Research

Joined Department

August 2004

Appointment

90% Research 
10% Teaching

Education

Ph.D., Plant Biology, University of Georgia, 2002
M.S., Plant Physiology, Yangzhou University, China, 1986
B.S., Plant Physiology and Biochemistry, Nanjing University, China, 1983

Research Interest 

My primary research objective is to explore the function of transposable elements (TEs) in order to understand the forces underlying eukaryotic genome diversification. It now seems clear that each genome possesses a unique spectrum of transposable elements and a varying proportion of these are active. An open question is how this diversity of TEs influences the evolutionary trajectory of the genomes in which they reside. I use both computational and molecular biology-based approaches to address this question and to analyze the ever-increasing database of genomic sequence from multiple plant species.

Selected Publications

  • Zhao, D., Ferguson, A. E., & Jiang, N. 2015. Transposition of a Rice Mutator-Like Element in the Yeast Saccharomyces cerevisiae. Plant cell. 27(1), 132-48.
  • Law, M., Childs, K. L., Campbell, M. S., Stein, J. C., Olson, A. J., Holt, C., Panchy, N., Lei, J., Jiao, D., Andorf, C. M., Lawrence, C. J., Ware, D., Shiu, S., Sun, Y., Jiang, N., & Yandell, M. 2015. Automated update, revision, and quality control of the maize genome annotations using MAKER-P improves the B73 RefGen_v3 gene models and identifies new genes. Plant physiology. 167(1), 25-39.
  • Zhao, D., Jiang, N. 2014. Nested Insertions and Accumulation of Indels are Negatively Correlated with Abundance of Mutator-Like Transposable Elements in Maize and Rice. PLoS ONE 9 (1): e87069.
  • Xu, Y., Jiang, N., Zou, Z., Tu, Z., Chen, A., Zhao, Q., Xiang, Z., and He, N. 2014. Retrotransposon “Qian” mediated segmental duplication in silkworm, Bombyx mori, Insect Biochem Mol Biol 46, 9-16.
  • Campbell, M. S., Law, M., Holt, C., Stein, J. C., Moghe, G. D., Hunagel, D. E., Lei, J., Achawanantakun, R., Jiao, D., Lawrence, C. J., Ware, D., Shiu, S-H., Childs, K. L., Sun, Y., Jiang, N, Yandell, M. 2014. MAKER-P: a tool-kit for the rapid creation, management, and quality control of plant genome annotations. Plant Physiology.164 513-524.
  • Ferguson, A., Zhao, D., and Jiang, N. 2013. Selective acquisition and retention of genomic sequences by Pack-MULEs based on GC content and breadth of expression. Plant Physiology. 163, 1419-1432.
  • Ferguson, A. A., Jiang, N. 2012. Mutator-like elements with multiple long terminal inverted repeats (TIR) in plants. Comparative and Functional Genomics. 2012.
  • Ferguson, A. A., Jiang, N. 2011. Pack-MULEs: recycling and reshaping genes through GC-biased acquisition.Mobile Genetic Elements 1:135-138.
  • Jiang, N., Ferguson, A. A., Slotkin, R. K., Lisch, D. 2011. Pack-Mutator-like transposable elements (Pack-MULEs) induce directional modification of genes through biased insertion and DNA acquisition. Proc Natl Acad Sci USA  108:1537-1542.
  • Ammiraju J.S., Fan C., Yu Y., Song X., Cranston K.A., Pontaroli A.C., Lu F., Sanyal A., Jiang N., Rambo T., Currie J., Collura K., Talag J., Bennetzen J.L., Chen M., Jackson S., Wing R.A. 2010. Spatio-temporal patterns of genome evolution in allotetraploid species of the genus Oryza. Plant J. 63:430-442.
  • Zhang, H., Liang, W., Yang, X., Luo, X., Jiang, N., Ma, H., Zhang, D. 2010. Carbon Starved Anther (CSA) Encoding a MYB Domain Protein Regulates Sugar Partitioning Required for Rice Pollen Development. Plant Cell  22(3):672-89.
  • Tsukamoto, T., Hauck, N.R., Tao, R., Jiang, N. and Iezzoni A.F. 2010. Molecular and Genetic Analyses of Four Non-Functional S Haplotype Variants Derived from a Common Ancestral S Haplotype Identified in Sour Cherry (Prunus cerasus L.) Genetics  184 (2):411-27.
  • Gao, D., Gill, N., Kim, H.R., Walling, J.G., Zhang, W., Fan, C., Yu, Y., Ma, J., Sanmiguel, P., Jiang, N., Cheng, Z., Wing, R.A., Jiang, J.and Jackson, S.A. 2009. A lineage-specific centromere retrotransposon in Oryza brachyantha. Plant J. 60 (5):820-831.
  • Jiang, N., Gao, D., Xiao, H. and van der Knaap, E. 2009. Genome organization of the tomato sun locus and characterization of the unusual retrotransposon Rider. Plant J. 60:181-193.
  • Hanada, K., Vallejo, V., Nobuta, K., Slotkin, R.K., Lisch, D., Meyers, B.C., Shiu, S.H. and Jiang, N. 2009. The Functional Role of Pack-MULEs in Rice Inferred from Purifying Selection and Expression Profile. Plant Cell21:25-38.
  • Lisch, D., and Jiang, N. 2009. Mutator and MULE transposons. In Handbook of Maize: Genetics and Genomics, J.L. Benntzen and S. Hake, eds (New York: Springer), pp.277-306.
  • Ammiraju, J.S., Lu, F., Sanyal, A., Yu, Y., Song, X., Jiang, N., Pontaroli, A.C., Rambo, T., Currie, J., Collura, K., Talag, J., Fan, C., Goicoechea, J.L., Zuccolo, A., Chen, J., Bennetzen, J.L., Chen, M., Jackson, S., and Wing, R.A. 2008. Dynamic evolution of Oryza genomes is revealed by comparative genomic analysis of a genus-wide vertical data set. Plant Cell 20:3191-3209.
  • Xiao H., Jiang N., Schaffner E., Stockinger E.J., van der Knaap E. 2008. A retrotransposon-mediated gene duplication underlies morphological variation of tomato fruit. Science 319:1527-1530
  • Ammiraju J.S.S., Zuccolo A., Yu Y., Song X., Piegu B., Chevalier F., Walling J.G., Ma J., Talag J., Brar D.S., SanMiguel P.J., Jiang N., Jackson S.A., Panaud O. and Wing R.A. 2007.  Evolutionary dynamics of an ancient retrotransposon family provides insights into evolution of genome size in the genus Oryza. Plant J. 52:342-51
  • Campbell, M.A., Zhu, W., Jiang, N., Haas, B.I., Lin, H., Ouyang, S., Childs, K.L., Hamilton, J.P., and Buell, C.R.. 2007. Identification and characterization of lineage-specific genes within the Poaceae. Plant Physiol.145:1311-22.
  • Zhang, S., Gu, Y.Q., Singh, J., Coleman-Derr, D., Brar, D.S., Jiang, N., Lemaux, P.G. 2007. New insights into Oryza genome evolution: high gene colinearity and differential retrotransposon amplification. Plant Mol Biol.64:589-600.
  • Holligan, D., Zhang, X., Jiang, N., Pritham, E.J. and Wessler, S.R. 2006. The transposable element landscape of the model legume Lotus japonicus. Genetics 174:2215-28.
  • Tsukamoto, T., Hauck, N.R., Tao, R., Jiang, N. and Iezzoni, A.F. 2006 Molecular characterization of three non-functional S-haplotypes in sour cherry (Prunus cerasus) Plant Mol Biol. 62:371-183 .
  • Zhang, S., Chen, C., Li, L., Meng, L., Singh, J, Jiang, N., Deng, X.W., He, Z.H. and Lemaux, P.G.2005. Evolutionary expansion, gene structure, and expression of the rice wall-associated kinase gene family. Plant Physiol. 139:1107-24.
  • Jiang, N., Bao, Z., Zhang, X., Eddy, S.R. and Wessler, S.R. 2004. Pack-MULE transposable elements mediate gene evolution in plants. Nature 431:569-573.
  • Feltus, F.A., Wan, J., Schulze, S.R., Estill, J.C., Jiang, N., and Paterson, A.H. 2004. An SNP resource for rice genetics and breeding based on subspecies indica and japonica genome alignments. Genome Res. 14:1812-9.
  • Jiang, N., Feschotte, C., Zhang, X., and Wessler, S.R. 2004. Using rice to understand the origin and amplification of MITEs. Curr. Opin. Plant Biol. 7:115-119.
  • Zhang, X., Jiang, N., Feschotte, C. and Wessler, S.R. 2004. PIF and Pong-like elements: distribution, evolution and relationship with the Tourist-like miniature inverted-repeat transposable elements. Genetics166:971-986.
  • Jiang, N., Bao, Z., Zhang, X., Hirochika, H., Eddy, S.R., McCouch, S.R. and Wessler, S.R. 2003. An active DNA transposon family in rice. Nature 421:163-167.
  • Jiang, N., Jordan, I.K. and Wessler, S.R. 2002. Dasheng and RIRE2: a non-autonomous LTR element and its putative autonomous partner in the rice genome. Plant Physiol. 130:1697-1705.
  • Jiang, N., Bao, Z., Temnykh, S., Cheng, Z., Jiang, J., Wing, R.A., McCouch, S.R. and Wessler, S.R.  2002.Dasheng: a recently amplified non-autonomous LTR element that is a major component of pericentromeric regions in rice. Genetics 161:1293-1305.
  • Feschotte, C., Jiang, N. and Wessler, S.R. 2002. Plant transposable elements: where genetics meets genomics. Nature Rev. Genet. 3:329-341.
  • Jiang, N. and Wessler, S.R. 2001. Insertion preference of maize and rice MITEs as revealed by the analysis of nested elements.  Plant Cell 13:2553-2564.
  • Zhang, X., Feshotte, C., Zhang, Q., Jiang, N., Eggelston, W.B. and Wessler, S.R. 2001. P Instability Factor: an active maize transposon system associated with the amplification of Tourist-like MITEs and a new superfamily of transposases. Proc. Natl. Acad. Sci. USA. 98:12572-12577.

Program Areas

Plant Breeding and Genetics

My primary research objective is to explore the function of transposable elements (TEs) in order to understand the forces underlying eukaryotic genome diversification. It now seems clear that each genome possesses a unique spectrum of transposable elements and a varying proportion of these are active. An open question is how this diversity of TEs influences the evolutionary trajectory of the genomes in which they reside. I use both computational and molecular biology-based approaches to address this question and to analyze the ever-increasing database of genomic sequence from multiple plant species.